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Ian Hulatt: Melancholy disputes over effectiveness of antidepressants

A huge review of the evidence has found antidepressants are more effective than placebos. But what works and what doesn’t in the treatment of depression is far from straightforward

A huge review of the evidence has found antidepressants are more effective than placebos. But what works and what doesn’t in the treatment of depression is far from straightforward

A disposition to melancholy, a disturbance in the humours or a biological disturbance remedied by a chemical preparation. The history of depression is almost a microcosm of societal and scientific approaches to mental distress.

While our colleagues in physical medicine never have to argue for the existence of the diseases they treat, life is not so simple in the world of depression.

There are those who see it as a rational response to overwhelmingly sad situations, or even a rational response to the very nature of the precarious self that we embody. There are

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