A to Z of syndromes

A-Z syndromes: Yunis-Varon syndrome

An insight into this rare genetic disorder in which both parents are recessive gene carriers
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An insight into this rare genetic disorder in which both parents are recessive gene carriers

Yunis-Varon syndrome is a rare genetic disorder, inherited as an autosomal recessive trait. This means that both parents have to be carriers of a recessive gene and the risk to the parents of having an affected child is 1:4 with each pregnancy.

Consanguinity between the parents increases the risk. The syndrome was first identified in 1980, by geneticists Yunis and Varon. It affects males and females, and has been identified in several races.

Children with the syndrome may be born without collarbones, can have cardiac anomalies, microcephaly, ear abnormalities, anteverted nares, midfacial hypoplasia, tented upper lip and micrognathia.

The hair of the eyebrows and eyelashes can be sparse or absent.

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