A to Z of syndromes

A-Z of syndromes: Qazi Markouizos syndrome

A series about disorders and diseases with common symptoms that constitute syndromes

A series about disorders and diseases with common symptoms that constitute syndromes

Qazi Markouizos syndrome is a rare disorder named after the paediatricians who first described the syndrome. The condition is characterised by hypotonia, seizures, delayed and dysharmonic skeletal maturation.

Dysharmonic skeletal maturation means that there is considerable inconsistency in the ossification and maturation of bones, mainly the bones of the hand despite reasonable overall physical growth and this has been reported as being fairly consistent between cases (Qazi et al 1994).

The syndrome can also cause constipation, in males the testicles are late to descend and in the children diagnosed there were complex learning differences. There may be some facial characteristics with widely spaced eyes and a long space between the root of the nose and the top lip (hypertelorism long philtrum) however these are quite subtle and less specific.

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