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Optimising bed rest period to reduce lumbar punctures after chemotherapy

Randomised controlled trial of bed rest optimisation to reduce obstacles in chemotherapies

Randomised controlled trial of bed rest optimisation to reduce complications in chemotherapies

The blood vessels that vascularise the central nervous system provide precise and protective properties controlling homeostasis through the physiological blockade termed the ‘blood-brain barrier’. Unfortunately, this protection from pathogens and toxins means that most systemic chemotherapeutic agents cannot pass across either, which is a problem as the central nervous system becomes a sanctuary site for malignant cells in diseases such as acute leukaemia.

The development of lumbar puncture (LP) and intrathecal chemotherapy (ITC) removed this cancerous haematological cell haven and has contributed to the overall effectiveness of treatments and survival outcomes. The procedure is associated with significant complications, such as post-procedural headache, back pain, nausea and vomiting, bleeding and infection. This multicentre, open-label randomised Chinese study examined the best time for reducing complications.

A total of 390 patients receiving


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