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A cluster randomised trial of strategies to increase cervical screening uptake at first invitation

Compiled by Vari Drennan, professor of health care and policy research, St Geroge’s University of London and Kingston University, London.

A cluster randomised trial of strategies to increase cervical screening uptake at first invitation

There has been an increase in the incidence of cervical cancer in women under 35, and a decrease in young women taking up cervical screening invitations.

While barriers such as embarrassment have been well documented, this cluster-randomised trial, based on general practices in Greater Manchester and the Grampian region, investigated the feasibility, clinical effectiveness and cost-effectiveness of a range of interventions to increase uptake in this age group.

In the first phase, of 20,879 women receiving their first invitation, half were randomised by practice to receive a pre-invitation leaflet. Those in Manchester had access to online appointment booking.

In the second phase, the 10,126 women who had not attended by six months were randomised by practice to receive one of:

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