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Reviews

Fatal Flaws – How a Misfolded Protein Baffled Scientists and Changed the Way We Look at the Brain

Neurological diseases caused by prions have received less media attention in recent years, but they still have the potential to cause harm.

Written in the form of a detective story, this engrossing account details the discovery of a novel disease agent that was identified as the cause of mad cow disease three decades ago. It charts how scientists competed to make sense of the data in front of them.

Merging biology, medicine, human tragedy and scientific rivalry, the author emphasises the potential of prion science which may unlock the answers to humankind’s most destructive diseases, such as Creutzfeldt-Jakob disease, Parkinson’s, Alzheimer’s and motor neurone disease, among others.

This book is written in an informal, engaging style while also making complex scientific concepts more accessible to the reader. Scientific references are also provided for those who wish to explore the topic in more detail.

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