New cell could guide immunotherapy for lung cancer
A newly discovered immune cell could predict which lung cancer patients would benefit most from immunotherapy treatment, according to a study.
Researchers at the University of Southampton and La Jolla Institute for Allergy and Immunology, California, found that lung cancer patients with large amounts of a particular type of immune T-cell, called tissue-resident memory T-cells, in their tumour were 34% less likely to die.
The Cancer Research UK-funded study found that the cells’ behaviour also increased survival. They clustered together and ‘took up residency’ in a particular tissue, in this case the cancer tissue, to protect the patient.
These T-cells also produce other molecules that attack the tumour, meaning that the body’s immune system could be more likely to destroy cancer cells.
Immunotherapies have shown great promise in the past decade, but identifying...
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