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Vitamin D supplementation effective in preventing acute respiratory tract infections

Studies have consistently shown low levels of vitamin D will leave people more susceptible to respiratory infections

Studies have consistently shown low levels of vitamin D will leave people more susceptible to respiratory infections.

Acute respiratory infections are a major cause of ill health and mortality. Observational studies have consistently shown that people with low levels of 25-hydroxyvitamin D, the major circulating vitamin D metabolite, are more susceptible to respiratory infection.

Vitamin D supports the development of antimicrobial peptides in response to viral and bacterial stimuli. This may be the mechanism by which it provides protection against infection.

This study combined data from 23 randomised, double-blind, placebo-controlled trials of supplementation with vitamin D. It found that daily or weekly supplementation protected against acute respiratory infection whereas large bolus doses did not.


The ineffectiveness of bolus doses of vitamin D may be related to fluctuating levels of 25-hydroxyvitamin unbalancing the enzyme responsible for


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