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Potential cardiovascular benefits of canagliflozin compared with other diabetes drugs

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Medications for type 2 diabetes have different modes of action. The various non-gliflozin drugs work by stimulating production of insulin, reducing glucagon which increases blood sugar levels or enhancing the action of insulin in the body.

Canagliflozin, by contrast, is a sodium-glucose co-transporter inhibitor, which means that it lowers blood sugar levels by blocking the reabsorption of glucose in the kidneys. When combined with a healthy lifestyle, these drugs have been shown to promote weight loss and regulate blood pressure and other cardiovascular markers as well as improving glycaemic control.

Cardiovascular disease is a leading cause of morbidity and mortality in patients with type 2 diabetes. In addition to atherosclerotic heart disease, patients are at increased risk of being admitted to hospital or dying with heart failure. Despite early indication of benefit, until

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