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Long-term proton pump inhibitor use does not increase hip fracture risk among people with Alzheimer's

Despite slight increase in risk over first year, study shows no increase in number of fractures over ten-year period 
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Despite slight increase in risk over first year, study shows no increase in number of fractures over ten-year period

Proton pump inhibitors (PPIs), whose main action is a reduction in the production of stomach acid, are effective drugs for dyspepsia, gastro-oesophageal reflux disease and peptic ulcer. They are commonly and increasingly prescribed for older people.

Due to their gastro-protective properties, they are also co-prescribed with non-steroidal anti-inflammatory drugs. Previous studies have suggested that use of these drugs is associated with a small increase in the risk of fractures.

This study aimed to investigate if long-term use of PPIs was associated with increased risk of hip fractures. It focused on people with Alzheimer’s disease for whom hip fracture is a major health problem. It was based on register data of all people living

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