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Injecting growth factor into diabetic foot ulcers may kick-start healing

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Berlanga-Acosta J, Fernández-Montequín J, Valdés-Pérez et al (2017) Diabetic foot ulcers and epidermal growth factor: revisiting the local delivery route for a successful outcome. BioMed Research International. doi:10.1155/2017/2923759

Diabetic foot ulcers are full-thickness wounds penetrating through the deep layers of the skin below the ankle in patients with diabetes.

They are much feared because they are difficult to heal and may lead to amputation of the limb.

Diabetes-related peripheral neuropathy and ischaemia due to vascular damage are responsible for the development and lack of healing of these ulcers.

Unlike in other wounds, there is a failure to trigger proliferation of granulation tissue, impaired wound contraction and alteration in the regrowth of epithelium.

Hyperglycaemia is the primary trigger for the toxic changes that lead to thickening of vessel walls, which reduces function in the vascular system.

Growth factor has

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