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Apomorphine infusion could reduce periods of immobility in people with Parkinson’s disease

Study assessed use of infusion to reduce ‘off time’ in patients with persistent motor fluctuations
Treating Parkinson's

Study assessed the use of apomorphine to reduce ‘off time ’ in patients with persistent motor fluctuations

Motor symptoms of Parkinson’s disease can initially be well controlled with oral dopamine replacement. Unfortunately, most people will experience motor fluctuations with periods of immobility or ‘off time’ as the disease progresses. When these problems first emerge, they can be treated by shortening the interval between levodopa tablets, increasing the dose, adding medication to increase availability of dopamine, or by using dopamine agonists which work by making dopamine more effective.

However, over time motor fluctuations usually continue to worsen leading to troubling periods of immobility, and attempts to control fluctuations can lead to disabling dyskinesia with its involuntary and uncontrollable jerky movements. Difficult-to-control motor symptoms can be treated with deep brain stimulation, intestinal infusion of levodopa-carbidopa gel or with


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