Journal scan

Fragile X and autism: treatments for hypersensitivity

Potential new research developments to improve sensory stimulation.
Fragile X chromosomes

Potential new research developments to improve sensory stimulation

It is recognised that people with fragile X and autism share common needs. In both conditions, for example, individuals can respond too readily to sensory stimulation, in the case of people with fragile X especially, this oversensitivity is due to overexcitement of the neurones. The overstimulation of the neuronal pathways leads to seizures and sensory hypersensitivity.

A protein – mGluR 5 – has been found to be in excess in individuals who have excitable neurones. Previous research has been attempted to inhibit overstimulation, but the treatments have failed to manipulate the protein itself. New developments however, have the potential for providing improvements.

Research is now being undertaken which aims to manipulate the module responsible for developing the mGluR 5 protein, therefore influencing the production of the protein before it is


Want to read more?

Unlock full access to RCNi Plus today

Save over 50% on your first three months:

  • Customisable clinical dashboard featuring 200+ topics
  • Unlimited online access to all 10 RCNi Journals including Learning Disability Practice
  • RCNi Learning featuring 180+ RCN accredited learning modules
  • NMC-compliant RCNi Portfolio to build evidence for revalidation
  • Personalised newsletters tailored to your interests

This article is not available as part of an institutional subscription. Why is this?