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Lactate levels in patients with suspected sepsis

Emergency department (ED) sepsis screening algorithms should incorporate a serum lactate cut off of ≥2mmol/L as a threshold for the initiation of interventions and increased monitoring, research concludes.
Sepsis

Emergency department (ED) sepsis screening algorithms should incorporate a serum lactate cut off of ≥2mmol/L as a threshold for the initiation of interventions and increased monitoring, research concludes.

Specific lactate thresholds for poor outcomes in patients presenting to EDs with suspected sepsis were subject to retrospective analysis.

Outcome data were sourced on 12,349 ED patients over three years from 97 sites across New South Wales, Australia. A total of 8,310 patients had initial serum lactate analysis on presenting to ED.

The researchers hypothesise that raised lactate levels of ≥2mmol/L predict higher risk of in-hospital mortality (IHM) or an intensive care unit (ICU) stay of 72 hours or longer.

The authors categorised lactate levels into ranges: <1, 1 to <2, 2 to <3, 3 to <4 and ≥4mmol/L. Patients who had experienced IHM or were in an ICU for

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