Journal scan

Haematologic neoplasm in survivors of breast cancer

Incidence of myeloid leukaemia and myelodysplasia are higher in women treated for breast cancer

Incidence of myeloid leukaemia and myelodysplasia are higher in women treated for breast cancer

Acute_myeloid_leukaemia
Picture: SPL

The primary objective of this French study was to evaluate the occurrence and prevalence of secondary haematological types in people living with and beyond breast cancer, but mainly female survivors.

Between 1 July 2006 and 31 December 2015, researchers collected and collated data from a nationwide health data system on 439,704 women diagnosed with breast cancer aged 20-85 years.

The women were followed up until haematologic malignant neoplasm occurrence - such as acute leukaemia, or myelodysplastic or myeloproliferative disorders - death, loss of follow-up or until December 31 2016, whichever came first. 

The results show that the incidence of diseases, such as acute myeloid leukaemia (AML) and myelodysplasia (MDS), were markedly higher in women treated for breast cancer than in women in the general population. The possibility of developing AML was three times higher, and that of MDS five times higher, than the standardised occurrence of the disease.

The occurrence of the secondary neoplasm increased after the initial breast cancer diagnosis, peaking at around the third year and again at the eighth year. A twofold incidence of secondary acute lymphoblastic leukaemia and lymphomas was also reported.

The researchers note there is a need to inform patients about the risks of developing AML and MDS.

There is also a need to consider how genetic information on treatment outcomes and adverse events could limit patient exposure to chemotherapeutic agents associated with the development of malignant disorders.

Jabagi MJ, Vey N, Goncalves A et al (2019) Evaluation of the incidence of haematologic neoplasm among breast cancer survivors in France. JAMA Network Open. 2, 1, e187147. doi:10.1001/jamanetworkopen.2018.7147

This article is for subscribers only

Jobs